| 产品介绍： |
产品简介：
Nalidixic acid sodium salt，一种喹诺酮类抗生素 (antibiotic)，对革兰氏阳性和革兰氏阴性细菌均有效。Nalidixic acid sodium salt 在较低浓度下以抑菌的方式起作用，而在较高浓度下具有杀菌作用。Nalidixic acid sodium salt 抑制 DNA 促旋酶和拓扑异构酶IV的亚基，并可逆地阻止易感细菌中的 DNA 复制。
储备液保存：
-80°C, 6 months; -20°C, 1 month
体外研究：
Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively.
体内研究：
The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli, A. aerobacter, Proteus mirabilis, Shigella fkxneri, the ED50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively. The acute toxicity (LD50) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg.
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。 |
中文
英文